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Targets Recommended: SARS-CoV

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60095	CCF0058981	SARS-CoV	Microbiology/Virology
	CCF0058981 (CCF981) 是3-氯苯基类似物，是一种非共价 SARS-CoV-2 3CLpro(SC2)抑制剂，IC50为 68 nM。CCF0058981 抑制 SC1 (SARS-CoV-1 3CLpro)，IC50为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。
T9574	PF-07304814 Lufotrelvir,卢夫特韦
	Lufotrelvir (PF-07304814) 是 PF-00835231 的磷酸盐前药，是一种有效的3CLpro 蛋白酶 (Mpro) 抑制剂，具有抗SARS-CoV-2 病毒活性。Lufotrelvir 结合并抑制 SARS-CoV-2 3CLpro 活性，Ki 为 174nM。Lufotrelvir 是一种很有前途的单一抗病毒试剂，也可用于与针对冠状病毒生命周期其他关键阶段的其他抗病毒试剂的联合研究。
T40320	Antiviral agent 5
	Antiviral agent 5 is a crucial intermediate utilized in the development of antiviral agents that specifically target 3C and 3CL proteases, which includes the SARS-CoV-2 M pro enzyme.
T79676	SARS-CoV-2 3CLpro-IN-21	Virus Protease	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-21（Compound D6）作为一种抑制剂，不可逆且共价地作用于SARS-CoV-2 3CLpro，展现出0.03μM的IC50值。该化合物同样对SARS-CoV-1 3CLpro具有抑制效果，其IC50为0.12 μM。
T75065	Antiviral agent 25
	Antiviral agent 25 (compound 6g) 是一种 SARS-CoV-2 3CLpro 新型非肽模拟共价抑制剂。Antiviral agent 25 对 SARS-CoV-2 3CLpro 和 SARS-CoV-2 PLpro 具有强抑制作用，IC50值分别为 0.118 µM、0.448 µM。Antiviral agent 25 对 SARS-CoV-2 具有抗病毒作用，EC50值为 7.249 µM。
T75241	Ledipasvir hydrochloride GS-5885 hydrochloride
	Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂，对GT1a 和 GT1b 复制子抑制作用显著，其EC50值仅为34 pM 和 4 pM。此外，Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro， IC50 为1.62 μM。
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T73898	Paritaprevir dihydrate
	Paritaprevir (ABT-450) dihydrate，一种口服非结构蛋白3/4A (NS3/4A) 蛋白酶抑制剂，对HCV1a 和 1b 具有高效抗病毒活性，EC50值分别为1 nM 和 0.21 nM。此外，其作为SARS-CoV3CLpro 抑制剂，IC50为1.31 μM。其主要通过细胞色素P450 (CYP) 3A代谢，且利托那韦 (Ritonavir，CYP450 抑制剂) 能增强其血浆浓度和延长半衰期。
T78119	Z-L(D-Val)G-CHN2	HSV	Microbiology/Virology
	Z-L(D-Val)G-CHN2（即Z-LVG-CHN2）是半胱氨酸蛋白酶抑制剂的异构体，作为一种三肽衍生物，模仿了人体半胱氨酸蛋白酶结合中心的部分结构。它可以抑制HSV，并且能有效阻断SARS-COV-2的3CL pro蛋白酶，从而抑制病毒活性（EC50=190 nM），但对脊髓灰质炎病毒复制无显著作用。

化合物

Synonym: Lufotrelvir,卢夫特韦

SARS-CoV-2 3CLpro-IN-21

Cat.No: T79676

Synonym:

Target: Virus Protease

Ledipasvir hydrochloride

Cat.No: T75241

Synonym: GS-5885 hydrochloride

Target:

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

Synonym:

Target:

Paritaprevir dihydrate

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) COVID-19,3CL Protease,M Pro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant M Proteinase,3C-like Proteinase,<...	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec...
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) M Proteinase,3CL Protein...	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t...